Lv12
62 积分 2025-06-30 加入
Cooperativity basis for small-molecule stabilization of protein–protein interactions
10分钟前
已完结
What Makes a Good Protein–Protein Interaction Stabilizer: Analysis and Application of the Dual-Binding Mechanism
2天前
已完结
Design and Synthesis of Pyrrolo[3,4- d ]pyrimidine-Based ATR Degraders for Effective Treatment of Colorectal Cancer in Mouse Model
3天前
已完结
Integrative Modeling of PROTAC-Mediated Ternary Complexes
5天前
已完结
Research Article: Selectivity‐determining Residues in Plk1
10天前
已完结
Polo-like kinase 1–inhibitor co-complex structures via the surface-entropy reduction approach and a DARPin-assisted approach
10天前
已关闭
Rational Design of Oxazolonylflavone Derivatives as Novel CDK4/9 Inhibitors with Potent Antitumor Efficacy and Oral Bioavailability
12天前
已完结
Structure-Based Design of 4-(1-Methyl-1 H -indol-3-yl)pyrimidin-2-amine Derivatives as the First Covalent FGFR3 Selective Inhibitors
24天前
已完结
Design, Synthesis and Biological Evaluation of 7-(1-Methyl-1H-indole-3-yl)-5H-pyrrolo[2,3-b]pyrazine Derivatives as Novel Covalent pan-FGFR Inhibitors to Overcome Clinical Resistance
24天前
已完结
Discovery and Optimization of 4-Aminopteridin-7(8H)-one Derivatives as Potent and Selective mTOR Inhibitors with Favorable Pharmacodynamic and Safety Characteristics
27天前
已完结
皖公网安备34019202002308
