Lv7
3504 积分 2022-10-24 加入
Discovery of N-(4-(2,4-Difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl)ethanesulfonamide (ABBV-075/Mivebresib), a Potent and Orally Available Bromodomain and Extraterminal Domain (BET) Family Bromodomain Inhibitor
3天前
已完结
Discovery of Novel CBP/p300 and BRD4 Dual-Target PROTACs with Potent Antitumor Activity in Prostate Cancer
1个月前
已完结
Discovery of ZX079 as a Dual PROTAC Degrader Targeting BRD4/CBP in Acute Myeloid Leukemia
1个月前
已完结
Discovery of Cdc20/Hsp90 Dual-Target Inhibitors with Potent Antitumor Activity for Therapy of Acquired Resistant Melanoma
1个月前
已完结
Evolving Strategiesfor Previously Drugged TherapeuticTargets: Medicinal Chemistry Insights from Paradigmatic Cases
1个月前
已完结
TRI-611, a selective, brain-penetrant molecular glue degrader of ALK
1个月前
已完结
Discovery of BMS-986449: A Potent, Selective Degrader of the Transcription Factors IKZF2 (Helios) and IKZF4 (Eos) to Target Regulatory T Cells in Solid Tumors
1个月前
已完结
Targeting KAT6A/B as a New Therapeutic Strategy for Cancer Therapy
2个月前
已完结
Application of Bioisosteres in the Design and Discovery of FDA-Approved Drugs and Advanced Clinical Candidates
3个月前
已完结
Mechanistic dissection of SMARCA2/4 molecular glues reveals programmable switching between DCAF16 and FBXO22
3个月前
已完结
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