Lv6
2568 积分 2024-12-24 加入
Discovery of Highly Potent and Orally Available CCNK Molecular Glue Degraders as Broad-Spectrum Antitumor Agents
2天前
已完结
Examining the Chirality, Conformation and Selective Kinase Inhibition of 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile (CP-690,550)
2天前
已完结
Discovery of CP-690,550: a potent and selective Janus kinase (JAK) inhibitor for the treatment of autoimmune diseases and organ transplant rejection
3天前
已完结
Discovery of YYSW001: A Highly Selective, Orally Bioavailable JAK1 Inhibitor Achieving Efficacy under a Moderate-Inhibition Strategy with Improved Preclinical Tolerability
3天前
已完结
The preclinical discovery and development of upadacitinib for the treatment of Crohn’s disease
3天前
已完结
JAK inhibitor selectivity: new opportunities, better drugs?
3天前
已完结
Deuterium in drug discovery: progress, opportunities and challenges
3天前
已完结
Pharmacological targeting of the JAK–STAT pathway: new concepts and emerging indications
3天前
已完结
Transcriptome-wide splicing network reveals specialized regulatory functions of the core spliceosome
5天前
已完结
JAK inhibitors in systemic lupus erythematosus: Translating pathogenesis into therapy
5天前
已完结
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