Lv1
100 积分 2022-06-07 加入
[Synthesis of 5'-derivatives of thymidine]
5天前
已关闭
Trivalent siRNA-Conjugates with Guanosine as ASGPR-Binder Show Potent Knock-Down In Vivo
7个月前
已完结
Exploring Chemically Modified Short Activating RNAs to Increase Stability against Nucleases and Enhance Gene Activation
7个月前
已关闭
Synthesis and Biophysical Properties of 3′-Deoxy-β- d -apio- d -furanosyl Nucleic Acids
7个月前
已完结
Shorter Is Better: The α-(l)-Threofuranosyl Nucleic Acid Modification Improves Stability, Potency, Safety, and Ago2 Binding and Mitigates Off-Target Effects of Small Interfering RNAs
11个月前
已完结
Expanding Conjugate Space of RNAi Therapeutics: Ligand at the 3′ End of the Antisense Strand Achieves Uncompromised In Vivo Potency and Efficacy and Reveals Interactions with the Argonaute-2 PAZ Domain
11个月前
已完结
Expanding the binding space of argonaute-2: incorporation of either E or Z isomers of 6′-vinylphosphonate at the 5′ end of the antisense strand improves RNAi activity
11个月前
已完结
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