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Fragment-to-Lead Medicinal Chemistry Publications in 2020
7天前
已完结
Covalent fragment libraries in drug discovery
7天前
已完结
Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit
7天前
已完结
An electrophilic fragment screening for the development of small molecules targeting caspase-2
7天前
已完结
Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor
7天前
已完结
X-ray Screening of an Electrophilic Fragment Library and Application toward the Development of a Novel ERK 1/2 Covalent Inhibitor
8天前
已完结
Discovery of a Covalent Inhibitor of KRASG12C (AMG 510) for the Treatment of Solid Tumors
8天前
已完结
The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity
8天前
已完结
K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions
8天前
已完结
Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening
11天前
已完结
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