Lv7
4580 积分 2022-10-26 加入
Preclinical translational physiologically based pharmacokinetic modeling for predicting human pharmacokinetics of proteolysis targeting chimeras: Case studies of vepdegestrant (ARV-471) and bavdegalutamide (ARV-110)
1个月前
已完结
Development of selective FGFR1 degraders using a Rapid synthesis of proteolysis targeting Chimera (Rapid-TAC) platform
2个月前
已完结
Discovery of potent and selective Bcl-2 inhibitors with acyl sulfonamide skeleton
5个月前
已完结
Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment
5个月前
已完结
The Roles of post-translational Modifications and Coactivators of STAT6 Signaling in Tumor Growth and Progression
9个月前
已完结
Glucose-dependent insulinotropic peptide and beyond: co-agonist innovations in the treatment of metabolic diseases
9个月前
已完结
The kinase ITK controls a Ca 2+ -mediated switch that balances T H 17 and T reg cell differentiation
10个月前
已完结
Discovery, optimization and biological evaluation of novel HBsAg production inhibitors
11个月前
已完结
Design, synthesis, and structure-activity relationship study of novel GLP-1/GIP/GCG triple receptor agonists
11个月前
已完结
First-Line Camizestrant for Emerging ESR1 -Mutated Advanced Breast Cancer
1年前
已完结
Non-rotational multi-channel endoscopic OCT for trajectory-resolved imaging in stereotactic brain biopsy
4天前
已采纳
Extinction drives recent thermophilization but does not trigger homogenization in forest understorey
4天前
已采纳
Nuclear-targeted GDOWN1 potently suppresses tumors by inducing premature transcription termination and exporting Pol Ⅱ CTD phosphatases to activate RB
4天前
已采纳
ATF3/SOX11-regulated FST activates IGF1R-ERK/AKT-Sp1 signaling to sustain trigeminal neuropathic pain
4天前
已采纳
Extending genome-wide association studies to admixed cohorts with high degrees of relatedness
1个月前
已采纳
Astrocytes viewed through the lens of their proteomes and subproteomes
1个月前
已采纳
Observation of superconductivity-induced leading-edge gap in a bilayer nickelate
1个月前
已采纳
PatB1 is an O-acetyltransferase that decorates secondary cell wall polysaccharides
1个月前
已采纳
Challenges and recommendations in establishing national human diversity genomic projects
2个月前
已采纳
皖公网安备34019202002308
