Lv41
428 积分 2025-07-02 加入
Dual inhibition of CHK1/FLT3 enhances cytotoxicity and overcomes adaptive and acquired resistance in FLT3-ITD acute myeloid leukemia
2小时前
已完结
Development of Dual FLT3 and CHK1 PROTACs for the Treatment of AML
2小时前
已完结
Reprogramming of cancer metabolism via photoresponsive nano-PROTAC enhances pyroptosis-mediated immunotherapy
4小时前
已完结
Chemical Proteomics Identifies RBBP7 as a New E3 Ligase Supporting Targeted Protein Degradation
4小时前
已完结
Small Molecule-Degrader Conjugates: Evaluating the Structure-Activity Relationship of Linkers to Overcome In Vivo Barriers in PROTAC Delivery
1个月前
已完结
Discovery of Potent Dual PROTAC Degraders Targeting BET-Kinase To Overcome FLT3 Inhibitor Resistance
1个月前
已完结
Linker Methylation as a Strategy to Enhance PROTAC Oral Bioavailability: Insights from Molecular Properties and Conformational Analysis
1个月前
已完结
Rational Design of Dual Degraders by Incorporating Molecular Glue Structural Features into PROTAC Degraders
2个月前
已完结
Discovery of P11–2: A Potent First-in-Class MNK1-Targeting PROTAC Degrader for the Treatment of Cancer
2个月前
已完结
Novel Amphiphilic PROTAC with Enhanced Pharmacokinetic Properties for ALK Protein Degradation
3个月前
已完结
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