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36 积分 2025-10-14 加入
Discovery of a Potent Chloroacetamide GPX4 Inhibitor with Bioavailability to Enable Target Engagement in Mice, a Potential Tool Compound for Inducing Ferroptosis In Vivo
13天前
已完结
Discovery of a novel P2X2/3 allosteric antagonist as an efficient bitter taste blocker
19天前
已完结
Discovery of a Potent, Orally Bioavailable Small-Molecule Inhibitor of Wildtype KIT with Exceptionally High Kinome Selectivity
28天前
已完结
An inhibitor of oxidative phosphorylation exploits cancer vulnerability
1个月前
已完结
Mutations in the SWI/SNF complex induce a targetable dependence on oxidative phosphorylation in lung cancer
1个月前
已完结
Discovery of XYD270 as a Potent, Selective, and Orally Efficacious BRD9 PROTAC for Cancer Therapy
1个月前
已完结
Abstract A049: Investigation of FHD-609, a potent degrader of BRD9, in preclinical models of acute myeloid leukemia (AML)
1个月前
已关闭
GNE-235: A Lead Compound Selective for the Second Bromodomain of PBRM1
1个月前
已完结
Targeting DCAF5 suppresses SMARCB1-mutant cancer by stabilizing SWI/SNF
1个月前
已完结
A Zirconium Aza-BODIPY Derivative as a Near-Infrared Fluorescent/Photoacoustic Imaging Bimodal Probe
1个月前
已完结
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