Lv6
1840 积分 2024-04-26 加入
Synthesis and structure–activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of Dorsomorphin: The discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe
4天前
已关闭
Biochemical and Structural Characterization of a Novel Class of Inhibitors of the Type 1 Insulin-like Growth Factor and Insulin Receptor Kinases
16天前
已完结
Allosteric inhibition of JAK2 with lysine-reactive compounds that bind the pseudokinase domain
16天前
已完结
Diethenyl Sulfoximine (DESI) as an Irreversible Lysine‐Targeting Warhead Enables the Design of Covalent Allosteric EGFR Inhibitor
16天前
已完结
Lysine-Targeted Covalent Inhibitors of PI3Kδ Synthesis and Screening by In Situ Interaction Upgradation
1个月前
已完结
Lysine-Reactive N-Acyl-N-aryl Sulfonamide Warheads: Improved Reaction Properties and Application in the Covalent Inhibition of an Ibrutinib-Resistant BTK Mutant
1个月前
已完结
Discovery and SAR Study of Boronic Acid-Based Selective PDE3B Inhibitors from a Novel DNA-Encoded Library
1个月前
已完结
Expanding the View of IKK: New Substrates and New Biology
3个月前
已完结
Design of a Lead-Like Cysteine-Targeting Covalent Library and the Identification of Hits to Cys55 of Bfl-1
3个月前
已完结
Design, Synthesis, and Activity Evaluation of Novel Nucleosides as ADAR1 Inhibitor for the Treatment of Prostate Cancer
3个月前
已完结
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