Lv3
280 积分 2024-12-27 加入
A neomorphic protein interface catalyzes covalent inhibition of RAS G12D aspartic acid in tumors
19小时前
待确认
Design, Synthesis, In Vitro and In Vivo Evaluation of Cereblon Binding Bruton’s Tyrosine Kinase (BTK) Degrader CD79b targeted Antibody Drug Conjugates
1个月前
已完结
Molecular chameleons in drug discovery
1个月前
已完结
Structure-Guided Optimization of 2-Aminoquinazoline Hematopoietic Progenitor Kinase 1 Inhibitors for Improved Oral Bioavailability and Synergistic Antitumor Immunity
2个月前
已完结
Discovery of INCB159020, an Orally Bioavailable KRAS G12D Inhibitor
3个月前
已完结
Reversible Small Molecule Multivariant Ras Inhibitors Display Tunable Affinity for the Active and Inactive Forms of Ras
3个月前
已完结
Discovery and Optimization of Pyrazine Carboxamide AZ3246, a Selective HPK1 Inhibitor
4个月前
已完结
Discovery of Elironrasib (RMC-6291), a Potent and Orally Bioavailable, RAS(ON) G12C-Selective, Covalent Tricomplex Inhibitor for the Treatment of Patients with RAS G12C-Addicted Cancers
5个月前
已完结
Dual-payload antibody–drug conjugates: Taking a dual shot
5个月前
已完结
Discovery of PF-07265028, A Selective Small Molecule Inhibitor of Hematopoietic Progenitor Kinase 1 (HPK1) for the Treatment of Cancer
6个月前
已完结
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