Lv41
510 积分 2023-11-29 加入
Lessons learned in linking PROTACs from discovery to the clinic
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A Once-Weekly C-Type Natriuretic Peptide for Treatment of Heart Failure with Preserved Ejection Fraction
29天前
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Structure-based design of macrocyclic peptides to generate functional antibodies against G protein-coupled receptors
30天前
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Targeted protein degradation in the transmembrane and extracellular space
1个月前
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Structure-Based Development of a Novel Macrocyclic Peptide to Disrupt the Lumican–Collagen I Interaction in Liver Fibrosis
1个月前
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Legumain-Cleavable Top1i Antibody-Drug Conjugates without Self-Immolative Spacers Demonstrate Potent Antitumor Activity
1个月前
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Fragment-Based Screening of NSD2-PWWP1 Identifies Novel Covalent Allosteric Ligands That Diminish Methyllysine and DNA Binding Abilities of NSD2
1个月前
已完结
Structure-Based Optimization of Imidazopyridine Derivatives as Selective and Orally Bioavailable Phosphodiesterase 10A Inhibitors with Reduced Blood–Brain Barrier Penetration for the Treatment of Idiopathic Pulmonary Fibrosis
1个月前
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Small Molecule-Drug Conjugates: An Emerging Drug Design Strategy for Targeted Therapeutics
1个月前
已完结