Lv12
60 积分 2025-12-03 加入
The MNK–eIF4E Signaling Axis Contributes to Injury-Induced Nociceptive Plasticity and the Development of Chronic Pain
4小时前
待确认
Progress in developing MNK inhibitors
6天前
已完结
Mnk2 and Mnk1 are essential for constitutive and inducible phosphorylation of eukaryotic initiation factor 4E but not for cell growth or development
8天前
已完结
Discovery of Imidazo[2,1-b][1,3,4]thiadiazole-Based MNK Inhibitors with Anti-inflammatory Efficacy via Dual Suppression of eIF4E Phosphorylation and NF-κB Signaling
8天前
已完结
Discovery of clinical candidate 4ET1103, a peripherally-restricted MNK inhibitor for the treatment of pain
8天前
已完结
Discovery of novel 7,7-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidines as ATR inhibitors based on structure-based drug design
1个月前
已完结
Anti-inflammatory effect of artemisinin on uric acid-induced NLRP3 inflammasome activation through blocking interaction between NLRP3 and NEK7
3个月前
已完结
Abstract 4366666: Selective Degradation of NIMA-related kinase 7 (NEK7) via a Molecular Glue Degrader Inhibits IL-1 Downstream of NLRP3 Inflammasome Activation: A Novel Therapeutic Approach for Cardiovascular Inflammation
3个月前
已关闭
Internalization, Trafficking, Intracellular Processing and Actions of Antibody-Drug Conjugates
5个月前
已完结
The effect of SGN-75, a novel antibody–drug conjugate (ADC), in treatment of patients with renal cell carcinoma (RCC) or non-Hodgkin lymphoma (NHL): A phase I study
5个月前
已关闭
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