Lv4
660 积分 2025-08-19 加入
Development of APH003─a Highly Potent, Selective, and Orally Bioavailable IRAK4 PROTAC Degrader for the Treatment of Inflammatory Diseases
21天前
已完结
Discovery of a selective CDK7 PROTAC against acute leukemia with low platelet toxicity
3个月前
已完结
Discovery of novel 2,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridine-7-one derivatives as PDE2 inhibitors with Alzheimer's disease therapeutic potential
6个月前
已完结
Design, synthesis, and induction of tumor ferroptosis activity of a novel FSP1 protein degrading agent
8个月前
已完结
Targeting YAP/TAZ–TEAD and Their Protein-protein Interaction for Precision Cancer Therapy
8个月前
已完结
PDE10A Inactivation Prevents Doxorubicin-Induced Cardiotoxicity and Tumor Growth
10个月前
已完结
Discovery of 3-trifluoromethyl-substituted pyrazoles as selective phosphodiesterase 10A inhibitors for orally attenuating isoprenaline-induced cardiac hypertrophy
10个月前
已完结
Key imidazolyl groups that induce phenylalanine flipping enhance the efficacy of oral BRD9 inhibitors for AML treatment
10个月前
已完结
Identification of Indoquinazoline Derivatives as Novel NR4A1 Agonists by Suppressing Adipocyte Lipogenesis for Treatment of Obesity
11个月前
已完结
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