Lv72
3578 积分 2024-06-21 加入
Discovery of pyrazole-based selective covalent ITK inhibitors with In vivo activity
8天前
已完结
Discovery of a Potent, Selective, and Orally Efficacious STAT6 PROTAC for the Treatment of Atopic Dermatitis
28天前
已完结
Discovery of Potential First-in-Class Dual Ligand-Directed Degrader and Antagonist of the Androgen Receptor: BMS-986365
2个月前
已完结
Discovery of Novel Bicyclic Pyrazole Amides as Potent Neuronal KV7 Potassium Channel Openers with Strong Preclinical Antiseizure Activity
2个月前
已完结
Differential activation of human pregnane X receptor PXR by isomeric mono-methylated indoles in intestinal and hepatic in vitro models
2个月前
已关闭
Design, Synthesis, and Biological Evaluation of a Cathepsin B-Activated Small Molecule-Drug Conjugate Targeting AKR1C3 to Enhance Chemotherapeutic Selectivity
3个月前
已完结
Structural Preferences and ADMET Regulation of Fluorinated Small-Molecule Drugs
3个月前
已完结
Discovery of BMS-986458, a Potent and Selective B-Cell Lymphoma 6 Protein Ligand-Directed Degrader, for the Treatment of B-Cell Non-Hodgkin Lymphoma
3个月前
已完结
Design of Potent and Selective BCL6 Transcriptional Chemical Inducers of Proximity through Linker Optimization
3个月前
已完结
Evaluation of Oral PROTAC Guidelines: Efflux Ratio Outweighs Chameleonicity Descriptors
3个月前
已完结
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