Lv11
46 积分 2023-03-22 加入
Design of PROTACs utilizing the E3 ligase GID4 for targeted protein degradation
1小时前
待确认
A novel cereblon modulator recruits GSPT1 to the CRL4CRBN ubiquitin ligase
22天前
已完结
Selective Degradation of GSPT1 by Cereblon Modulators Identified via a Focused Combinatorial Library
22天前
已完结
Mining the CRBN target space redefines rules for molecular glue–induced neosubstrate recognition
22天前
已完结
Discovery of APH02174 as a Highly Selective and Orally Bioavailable IRAK4 Degrader for the Treatment of Inflammatory Diseases
1个月前
已完结
Rational discovery of molecular glue degraders via scalable chemical profiling
1个月前
已完结
CRISPR Screen Reveals BRD2/4 Molecular Glue-like Degrader via Recruitment of DCAF16
1个月前
已完结
α-mangostin derivative 4e as a PDE4 inhibitor promote proteasomal degradation of alpha-synuclein in Parkinson's disease models through PKA activation
1个月前
已完结
Discovery of Small-Molecule Degraders for Alpha-Synuclein Aggregates
1个月前
已完结
Discovery of BIO-8169─A Highly Potent, Selective, and Brain-Penetrant IRAK4 Inhibitor for the Treatment of Neuroinflammation
2个月前
已完结
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