Lv32
236 积分 2025-08-08 加入
Thermodynamic and structural insights into the repurposing of drugs that bind to SARS-CoV-2 main protease
3天前
已完结
Targeted Protein Degradation and Metabolic Inhibition as Complementary Therapeutic Strategies: TEAD PROTACs and NAT8L Inhibitors in Oncology
6天前
已关闭
Discovery of an Androgen Receptor Degrader Featuring a Pyridazinyl Glutarimide CRBN-Binding Motif for Transdermal Treatment of Androgenetic Alopecia
6天前
已完结
Discovery of a Potent, Selective and In Vivo Active Aurora A PROTAC Degrader from a Promiscuous Kinase Inhibitor
6天前
已完结
From Scaffold Optimization to a Promising Lead: Discovery of a Novel Roemerine Analogue, a Multichannel Antiarrhythmic with Low hERG Liability and Functional Restoration Capacity
7天前
已完结
Novel Second-Generation Di-2-Pyridylketone Thiosemicarbazones Show Synergism with Standard Chemotherapeutics and Demonstrate Potent Activity against Lung Cancer Xenografts after Oral and Intravenous Administration in Vivo
12天前
已完结
Identification of the Piperidyl Urea Derivative BAY-439 as a Potent and Selective Inhibitor of Human Phospholipase A2 Group V (hPLA2-G5) for the Treatment of Inflammatory Pain
14天前
已完结
Targeting Multiple KRAS Mutations with High-Affinity Macrocyclic Inhibitors: From Discovery to Preclinical Validation
14天前
已完结
Triazinobenzoxazepine Derivatives Identified as Dual-Chitinase Inhibitors to Regulate Insect Growth
14天前
已完结
HDAC3 and HDAC8 PROTAC dual degrader reveals roles of histone acetylation in gene regulation
20天前
已完结
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