Lv2
186 积分 2025-03-04 加入
Discovery of 5-(Pyrimidin-2-ylamino)-1H-indole-2-carboxamide Derivatives as Nur77 Modulators with Selective and Potent Activity Against Triple-Negative Breast Cancer
5小时前
已完结
Structure-Based Design and Optimization of Bi-Aryl Amide Derivatives as Nur77 Ligands for Nur77-Bcl-2-Dependent Apoptotic Cancer Therapy
5小时前
待确认
Discovery of a “First-in-Class” Selective Multikinase (CDK4/6/9-AURKA/B) Inhibitor, LCI133, for Neuroblastoma
9天前
已完结
Macrocycles for Conventionally Druggable Targets: Lessons from Macrocyclic Kinase Inhibitors
2个月前
已完结
A Data-Driven Perspective on Bioisostere Evaluation: Mapping the Benzene Bioisostere Landscape with BioSTAR
2个月前
已完结
Discovery of degrader for FLT3, GSPT1 and IKZF1/3 proteins merging PROTAC and molecular glue targeting FLT3-ITD mutant acute myeloid leukemia
4个月前
已完结
Discovery and Characterization of RP03707: A Highly Potent and Selective KRASG12D PROTAC
6个月前
已完结
Discovery of Potent, Highly Selective, and Orally Bioavailable MTA Cooperative PRMT5 Inhibitors with Robust In Vivo Antitumor Activity
6个月前
已完结
Medoxomil Prodrug Strategies
6个月前
已完结
Discovery of the Clinical Candidate YY2201 as a Highly Potent and Selective ATR Inhibitor
8个月前
已完结
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