Lv4
408 积分 2025-03-04 加入
An alkyl-swap platform for late-stage modification of secondary N-methylamines
2天前
已完结
Discovery of the Orally Bioavailable Isoform Selective Janus Kinase 1 (JAK1) Compound Povorcitinib (INCB054707) for the Treatment of Inflammatory and Autoimmune Diseases
2天前
已完结
Discovery of an Androgen Receptor Degrader Featuring a Pyridazinyl Glutarimide CRBN-Binding Motif for Transdermal Treatment of Androgenetic Alopecia
2天前
已完结
Structural Basis for Long Residence Time c-Src Antagonist: Insights from Molecular Dynamics Simulations
28天前
已完结
Discovery of PKMYT1 Inhibitors with a Novel Scaffold for the Treatment of Triple-Negative Breast Cancer
29天前
已完结
Discovery of Tetracyclic Derivatives as Highly Potent, Selective, and Bioavailable PKMYT1 Inhibitors for Cancer Therapy
29天前
已完结
Innovative Medicinal Chemistry Strategies for Improving Target Binding Kinetics in Drug Discovery
29天前
已完结
Discovery and Optimization of a Potent, Efficacious, and Brain-Penetrant Inhibitor of KRAS G12C
3个月前
已完结
Discovery and Characterization of Divarasib (GDC-6036), a Potent Covalent Inhibitor of KRAS G12C
3个月前
已完结
MYC in cancer: from undruggable target to clinical trials
3个月前
已完结
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