Lv41
470 积分 2025-03-04 加入
Discovery of Highly Efficacious CRBN-Based KRAS Degraders Targeting Cancers with KRAS G12D and G12V Mutations
1小时前
已完结
Development of APH003─a Highly Potent, Selective, and Orally Bioavailable IRAK4 PROTAC Degrader for the Treatment of Inflammatory Diseases
30天前
已完结
Discovery of SMD-6346: A Potent, Selective, and Orally Active SMARCA2 Degrader for Targeting SMARCA4-Deficient Human Cancers
30天前
已完结
Potent and isoform-selective PARP1 degraders for the treatment of BRCA-deficient cancers
1个月前
已完结
Identification of XZ8078 as a Dual-Target Degrader Targeting PARP1 and IKZF3 for Broad Spectrum Anticancer Treatment
1个月前
已完结
An alkyl-swap platform for late-stage modification of secondary N-methylamines
1个月前
已完结
Discovery of the Orally Bioavailable Isoform Selective Janus Kinase 1 (JAK1) Compound Povorcitinib (INCB054707) for the Treatment of Inflammatory and Autoimmune Diseases
1个月前
已完结
Discovery of an Androgen Receptor Degrader Featuring a Pyridazinyl Glutarimide CRBN-Binding Motif for Transdermal Treatment of Androgenetic Alopecia
1个月前
已完结
Structural Basis for Long Residence Time c-Src Antagonist: Insights from Molecular Dynamics Simulations
2个月前
已完结
Discovery of PKMYT1 Inhibitors with a Novel Scaffold for the Treatment of Triple-Negative Breast Cancer
2个月前
已完结
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