Lv24
131 积分 2021-01-05 加入
Target identification and assessment in the era of AI
8小时前
已完结
SHP2 Inhibition Reveals Compensatory PI3K-AKT Activation in KRAS-Driven Pancreatic Cancer: Discovery of SDUY104 and Rational Approaches for Combination Therapy
1天前
已完结
Discovery of 4-Amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide (AZD5363), an Orally Bioavailable, Potent Inhibitor of Akt Kinases
3天前
已完结
Discovery of Casdatifan, Part II: A Potent and Orally Bioavailable Inhibitor of Hypoxia Inducible Factor-2α
3天前
已完结
Discovery of Casdatifan, Part I: Design and Characterization of Tetrahydroquinoline Inhibitors of Hypoxia-Inducible Factor-2α
3天前
已完结
Syntheses of Potent, Selective, and Orally Bioavailable Indazole-Pyridine Series of Protein Kinase B/Akt Inhibitors with Reduced Hypotension
6天前
已完结
Therapeutic Path to Triple Knockout: Investigating the Pan-inhibitoryMechanisms of AKT, CDK9, and TNKS2 by a Novel 2-phenylquinazolinoneDerivative in Cancer Therapy- An In-silico Investigation Therapy
7天前
已完结
Targeting PRMT9 Overcomes Venetoclax Resistance in AML by Modulating Splicing and Inhibiting Translation
7天前
已完结
Innovative dual-target AKT inhibitors unveiling novel mechanisms and translational potential
8天前
已完结
Discovery of YTB53, a Marine-Derived MNK-Active Anti-Acute Myeloid Leukemia Lead with Multi-Kinase Activity
9天前
已完结
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