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57 积分 2021-01-05 加入
Design, Synthesis, and Evaluation of a Potent NLRP3 Inflammasome Inhibitor with Favorable Pharmacokinetic and Safety Profiles for Chronic Inflammatory Diseases
18小时前
已完结
Discovery of Quinoline-Based Highly Potent and Selective THRβ Agonists for MASLD Treatment
3天前
已完结
Beyond CRBN and VHL: DCAF16-Recruiting Degraders from Rational Design to Clinical Translation
3天前
已完结
Discovery and Optimization of Isoform Selective ULK1 Degraders to Enhance Antitumor Activity in KRAS-Mutant Cancer
4天前
已完结
MEK Inhibitors
4天前
已完结
Macrocyclic MEK1/2 inhibitor with efficacy in a mouse model of cardiomyopathy caused by lamin A/C gene mutation
4天前
已完结
RIMTAC: A Novel Degrader Design Platform by Indirect VHL-Recruitment via RIPK1
5天前
已完结
Structure-Guided Discovery of Non-Peptide Macrocyclic KEAP1−NRF2 Inhibitors Targeting Cuproptosis in Depression
6天前
已完结
N-(Acyloxyalkoxycarbonyl) derivatives as potential prodrugs of amines. I. kinetics and mechanism of degradation in aqueous solutions
7天前
已完结
(Acyloxy)alkyl carbamates as novel bioreversible prodrugs for amines: increased permeation through biological membranes
7天前
已完结
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