Lv33
261 积分 2021-01-05 加入
Discovery of a Novel Lung-Restricted ALK5 Inhibitor for the Treatment of Idiopathic Pulmonary Fibrosis
6小时前
已完结
Targeting Multiple KRAS Mutations with High-Affinity Macrocyclic Inhibitors: From Discovery to Preclinical Validation
6小时前
已完结
Mapping the ATP-Binding Pockets of FLT3 and TAK1: A Structural Basis for Dual Inhibition by FLT3-Targeted Therapies
1天前
已完结
Dual Allosteric Targeting of SHP2: Development of Bivalent Inhibitors with Enhanced Potency for Cancer Treatment
5天前
已完结
Sulfonyl Pyrazoles as Sustainable Dual Functional Group Transfer Reagents: AlCl3 Promoted Transfer of Sulfonyl and Pyrazole Groups
6天前
已完结
Development of a Direct-to-Biology Platform to Discover Potent MNK Inhibitors
6天前
已完结
PI3K Regulates Wild-type RAS Signaling to Confer Resistance to KRAS Inhibition
7天前
已完结
Discovery of N-Phenyl-4-(1H-pyrrol-3-yl)pyrimidin-2-amine Derivatives as Potent Mnk2 Inhibitors: Design, Synthesis, SAR Analysis, and Evaluation of in vitro Anti-leukaemic Activity
9天前
已完结
Pharmacologic Inhibition of MNKs in Acute Myeloid Leukemia
9天前
已完结
Design, Structure–Activity Relationships, and In Vivo Evaluation of Potent and Brain-Penetrant Imidazo[1,2-b]pyridazines as Glycogen Synthase Kinase-3β (GSK-3β) Inhibitors
11天前
已完结
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