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26 积分 2021-07-13 加入
Discovery and Optimization of Triazolopyrimidinone Derivatives as Selective NLRP3 Inflammasome Inhibitors
1天前
已完结
Discovery of Novel NLRP3 Inflammasome Inhibitors Composed of an Oxazole Scaffold Bearing an Acylsulfamide
1天前
已完结
Optimization of novel TRPV1 antagonists bearing 1-((2,2-difluorobenzo[d][1,3] dioxol-5-yl) methyl) piperazine for pain management: Mechanistic insights into NLRP3 Inflammasome modulation
7天前
已完结
Discovery of NP3-253, a Potent Brain Penetrant Inhibitor of the NLRP3 Inflammasome
8天前
已完结
Dehydrocostus Lactone Effectively Alleviates Inflammatory Diseases by Covalently and Irreversibly Targeting NLRP3
8天前
已完结
Scaffold Hybrid of the Natural Product Tanshinone I with Piperidine for the Discovery of a Potent NLRP3 Inflammasome Inhibitor
8天前
已完结
Discovery of potent and selective inhibitors of human NLRP3 with a novel mechanism of action
12天前
已完结
Inhibition of NLRP3 by a CNS-penetrating indazole scaffold
15天前
已完结
Discovery of CZL-149: A Novel, Highly Potent, and Orally Bioavailable Dual Inhibitor Targeting BET and p300/CBP Bromodomains with Strong Antitumor Efficacy
15天前
已完结
Discovery of CNS Penetrant SOS1 Inhibitors for the Treatment of KRAS-Dependent Cancers
1个月前
已完结
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