Lv7
3440 积分 2021-05-28 加入
Advances in covalent kinase inhibitors
1天前
待确认
Structure-Guided Discovery of OAT-4828 as Potent, Selective, and Orally Bioavailable USP7 Inhibitor with In Vivo Antileukemic Activity
17天前
已完结
Design of Cyclic Vinyl Sulfones as WRN Covalent Inhibitors from Noncovalent Binders
17天前
已完结
A Small-Molecule Drug Conjugate Targeting FAP Exhibits Potent Activity in Dogs with Spontaneous Tumors
17天前
已完结
Rational Design of Small-Molecule Stabilizers of Human Fumarylacetoacetate Hydrolase for the Treatment of Tyrosinemia Type I
17天前
已完结
Antibody-Mediated Delivery of BRM/BRG1 Protein Degraders Affords Strong Antitumor Efficacy in Multiple BRM-Dependent Non-Small Cell Lung Cancer Xenograft Models
17天前
已完结
Development of a Direct-to-Biology Platform to Discover Potent MNK Inhibitors
17天前
已完结
Discovery of CZL-149: A Novel, Highly Potent, and Orally Bioavailable Dual Inhibitor Targeting BET and p300/CBP Bromodomains with Strong Antitumor Efficacy
17天前
已完结
Potent Benzothiazole-Triazole RIPK1/RIPK3 Dual-Targeting Inhibitors for the Treatment of Systemic Inflammatory Response Syndrome
17天前
已完结
Reverse Fosmidomycin Analogs as Bisubstrate Inhibitors: Binding Mode Elucidation and Mechanistic Insights
17天前
已完结
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