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160 积分 2021-05-29 加入
New PROTAC Designs for Targeted Protein Degradation in 2021–2025: Novel E3 Ligases and Pre-PROTACs
1个月前
已完结
Discovery of the First Potent PI3K/mTOR Dual-Targeting PROTAC Degrader for Efficient Modulation of the PI3K/AKT/mTOR Pathway
5个月前
已完结
Development of Small Molecule Chimeras That Recruit AhR E3 Ligase to Target Proteins
5个月前
已完结
Functional Characterization of Pathway Inhibitors for the Ubiquitin-Proteasome System (UPS) as Tool Compounds for CRBN and VHL-Mediated Targeted Protein Degradation
5个月前
已完结
Progress in RAS‐targeted therapeutic strategies: From small molecule inhibitors to proteolysis targeting chimeras
8个月前
已完结
Harnessing the SPOP E3 Ubiquitin Ligase via a Bridged Proteolysis Targeting Chimera (PROTAC) Strategy for Targeted Protein Degradation
8个月前
已完结
P4ward: An Automated Modeling Platform for Protac Ternary Complexes
8个月前
已完结
Structure-Based Design of Transport-Specific Multitargeted One-Carbon Metabolism Inhibitors in Cytosol and Mitochondria
9个月前
已完结
Accelerating Medicinal Chemistry: A C(sp3)-rich Fragment Toolbox for Redox-Neutral Cross-Coupling
9个月前
已完结
PSMAx-Guided PROTAC Degraders for Tumor-Specific Protein Degradation in Prostate Cancer
10个月前
已完结
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