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36 积分 2024-02-23 加入
Misconceptions among medicinal chemists regarding ADME and PK optimization
8小时前
待确认
Real-world effectiveness comparison of first-line palbociclib, ribociclib or abemaciclib plus endocrine therapy in advanced HR-positive/HER2-negative BC patients: results from the multicenter PALMARES-2 study
6天前
已完结
Hijacking ERAD for targeted degradation of transmembrane proteins
1个月前
已完结
Expanding the targeted protein degradation approach with small molecule chimeras directed to the 26S proteasome
1个月前
已完结
Structure-Based Discovery of HS34: A Highly Selective and Orally Bioavailable CDK9 Inhibitor for Triple-Negative Breast Cancer
1个月前
已完结
Metabolic Stability of Fluorinated Small Molecules: A Physical Organic Chemistry Perspective
1个月前
已完结
Discovery of AK-1690: A Potent and Highly Selective STAT6 PROTAC Degrader
3个月前
已完结
A small-molecule VHL molecular glue degrader for cysteine dioxygenase 1
3个月前
已完结
Discovery of Selective and Orally Bioavailable Heterobifunctional Degraders of Cyclin-Dependent Kinase 2
5个月前
已完结
Optimizing Shape Complementarity Enables the Discovery of Potent Tricyclic BCL6 Inhibitors
8个月前
已完结
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