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48 积分 2026-01-11 加入
Discovery of electrophilic degraders that exploit SNAr chemistry
5天前
已关闭
Exploring 2-Sulfonylpyrimidine Warheads as Acrylamide Surrogates for Targeted Covalent Inhibition: A BTK Story
10天前
已完结
Discovery of a molecular glue for EGFR degradation
24天前
已完结
Covalent Molecular Glues: Mechanisms, Design Principles, and Emerging Therapeutic Opportunities in Targeted Protein Degradation
25天前
已完结
Converting FGFR inhibitors into selective covalent molecular glue degraders via transposable gluing handles
25天前
已完结
Engineering ERα degraders with pleiotropic ubiquitin ligase ligands maximizes therapeutic efficacy by co-opting distinct effector ligases
1个月前
已完结
Discovery of TBK1Molecular Glue Degraders as a Potential Strategy for the Treatment of Autosomal Dominant Polycystic Kidney Disease (ADPKD)
1个月前
已完结
A Dual-Target and Dual-Mechanism Design Strategy by Combining Inhibition and Degradation Together
1个月前
已完结
RetroScore: graph edit distance-guided retrosynthesis for accessibility scoring with route metrics
1个月前
已完结
Leveraging intracellular ALDH1A1 activity for selective cancer stem-like cell labeling and targeted treatment via in vivo click reaction
2个月前
已完结
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