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50 积分 2025-10-30 加入
BioEmu is a biomolecular emulator for sampling protein structure ensembles
3小时前
求助中
CDK2 heterobifunctional degraders co-degrade CDK2 and cyclin E resulting in efficacy in CCNE1-amplified and overexpressed cancers
26天前
已完结
New strategy for renal fibrosis: Targeting Smad3 proteins for ubiquitination and degradation
1个月前
已关闭
K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions
2个月前
已完结
Inhibition mechanism of MRTX1133 on KRASG12D: a molecular dynamics simulation and Markov state model study
3个月前
已完结
Pathways and mechanism of MRTX1133 binding to KRAS G12D elucidated by molecular dynamics simulations and Markov state models
3个月前
已完结
GAP positions catalytic H-Ras residue Q61 for GTP hydrolysis in molecular dynamics simulations, complicating chemical rescue of Ras deactivation
3个月前
已关闭
Underappreciated Chemical Interactions in Protein–Ligand Complexes
3个月前
已完结
Underappreciated Chemical Interactions in Protein–Ligand Complexes
3个月前
已关闭
Identification of functional substates of KRas during GTP hydrolysis with enhanced sampling simulations
3个月前
已关闭
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