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60 积分 2025-10-30 加入
K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions
21天前
已完结
Inhibition mechanism of MRTX1133 on KRASG12D: a molecular dynamics simulation and Markov state model study
1个月前
已完结
Pathways and mechanism of MRTX1133 binding to KRAS G12D elucidated by molecular dynamics simulations and Markov state models
1个月前
已完结
GAP positions catalytic H-Ras residue Q61 for GTP hydrolysis in molecular dynamics simulations, complicating chemical rescue of Ras deactivation
1个月前
已关闭
Underappreciated Chemical Interactions in Protein–Ligand Complexes
1个月前
已完结
Underappreciated Chemical Interactions in Protein–Ligand Complexes
1个月前
已关闭
Identification of functional substates of KRas during GTP hydrolysis with enhanced sampling simulations
1个月前
已关闭
Pathways and mechanism of MRTX1133 binding to KRAS G12D elucidated by molecular dynamics simulations and Markov state models
2个月前
已完结
Reversible Small Molecule Multivariant Ras Inhibitors Display Tunable Affinity for the Active and Inactive Forms of Ras
2个月前
已完结
Novel 2-thiopyrimidine derivatives as CDK2 inhibitors: molecular modeling, synthesis, and anti-tumor activity evaluation
3个月前
已完结
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