Lv11
60 积分 2025-10-30 加入
Identification of functional substates of KRas during GTP hydrolysis with enhanced sampling simulations
1小时前
求助中
Pathways and mechanism of MRTX1133 binding to KRAS G12D elucidated by molecular dynamics simulations and Markov state models
17天前
已完结
Reversible Small Molecule Multivariant Ras Inhibitors Display Tunable Affinity for the Active and Inactive Forms of Ras
1个月前
已完结
Novel 2-thiopyrimidine derivatives as CDK2 inhibitors: molecular modeling, synthesis, and anti-tumor activity evaluation
1个月前
已完结
Discovery and preclinical evaluations of TQB3616, a novel CDK4-biased inhibitor
1个月前
已完结
Identifying Structure–Activity Relationships for Cyanine-Derived Antibiotics Using Machine Learning and Commercial Large Language Models
1个月前
已完结
The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity
1个月前
已完结
Discovery of Daraxonrasib (RMC-6236), a Potent and Orally Bioavailable RAS(ON) Multi-selective, Noncovalent Tri-complex Inhibitor for the Treatment of Patients with Multiple RAS-Addicted Cancers
1个月前
已完结
Small-Molecule Inhibitors Directly Targeting KRAS as Anticancer Therapeutics
1个月前
已完结
12 - The emergence of pan-KRAS drugs
1个月前
已关闭
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