Lv7
4110 积分 2021-12-12 加入
Discovery of AZD4747, a Potent and Selective Inhibitor of Mutant GTPase KRASG12C with Demonstrable CNS Penetration
2天前
已完结
Discovery of an Orally Bioavailable and Brain Penetrant Selective Estrogen Receptor Degrader
2天前
已完结
Discovery of Brain-Penetrative Negative Allosteric Modulators of NMDA Receptors Using FEP-Guided Structure Optimization and Membrane Permeability Prediction
2天前
已完结
Small Molecule Kinase Inhibitors for the Treatment of Brain Cancer
4天前
已完结
Discovery of a Hydroxylamine-Based Brain-Penetrant EGFR Inhibitor for Metastatic Non-Small-Cell Lung Cancer
9天前
已完结
Identifying Substructures That Facilitate Compounds to Penetrate the Blood–Brain Barrier via Passive Transport Using Machine Learning Explainer Models
9天前
已完结
A Chemical Strategy toward Novel Brain-Penetrant EZH2 Inhibitors
10天前
已完结
Discovery of Clinical Development Candidate GDC-0084, a Brain Penetrant Inhibitor of PI3K and mTOR
10天前
已完结
Development of a Potent Brain-Penetrant EGFR Tyrosine Kinase Inhibitor against Malignant Brain Tumors
11天前
已完结
Discovery and Optimization of a Potent, Efficacious, and Brain-Penetrant Inhibitor of KRAS G12C
15天前
已完结
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