Lv7
4130 积分 2021-12-12 加入
Thousands of chemical starting points for antimalarial lead identification
7天前
已完结
Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design
8天前
已完结
Discovery of Daraxonrasib (RMC-6236), a Potent and Orally Bioavailable RAS(ON) Multi-selective, Noncovalent Tri-complex Inhibitor for the Treatment of Patients with Multiple RAS-Addicted Cancers
13天前
已完结
Discovery ofLAS194046: A Potent and Selective pan-JanusKinase (JAK) Inhibitor with a Suitable Profile for Inhaled Administration
14天前
已完结
Discovery of AZD4747, a Potent and Selective Inhibitor of Mutant GTPase KRASG12C with Demonstrable CNS Penetration
1个月前
已完结
Discovery of an Orally Bioavailable and Brain Penetrant Selective Estrogen Receptor Degrader
1个月前
已完结
Discovery of Brain-Penetrative Negative Allosteric Modulators of NMDA Receptors Using FEP-Guided Structure Optimization and Membrane Permeability Prediction
1个月前
已完结
Small Molecule Kinase Inhibitors for the Treatment of Brain Cancer
1个月前
已完结
Discovery of a Hydroxylamine-Based Brain-Penetrant EGFR Inhibitor for Metastatic Non-Small-Cell Lung Cancer
1个月前
已完结
Identifying Substructures That Facilitate Compounds to Penetrate the Blood–Brain Barrier via Passive Transport Using Machine Learning Explainer Models
1个月前
已完结
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