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34 积分 2025-01-09 加入
Structure-guided design of 7-azaindole DNMT1 inhibitors active against hypomethylating agent-resistant acute myeloid leukemia
14天前
已完结
TOM20-driven E3 ligase recruitment regulates mitochondrial dynamics through PLD6
14天前
已完结
Identification of an allosteric site on the E3 ligase adapter cereblon
29天前
已完结
The MEK–RAF molecular glue IK-595 has potent antitumor activity across RAS/MAPK pathway-altered cancers
3个月前
已完结
Small Molecule–Degrader Conjugates: Evaluating the Structure–Activity Relationship of Linkers to Overcome In Vivo Barriers in PROTAC Delivery
3个月前
已完结
Full-Scale Manipulation of the Empty Bed Contact Time to Optimize Dissolved Organic Matter Removal by Drinking Water Biofilters
3个月前
已完结
Rational design of VHL-recruiting KRASG12C proteolysis-targeting chimeras based on molecular dynamics simulation
3个月前
已完结
Key imidazolyl groups that induce phenylalanine flipping enhance the efficacy of oral BRD9 inhibitors for AML treatment
3个月前
已完结
P4HA2 induces hepatic ductular reaction and biliary fibrosis in chronic cholestatic liver diseases
3个月前
已完结
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