Lv11
40 积分 2025-12-04 加入
Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15
2小时前
待确认
MYC-Targeting PROTACs Lead to Bimodal Degradation and N-Terminal Truncation
14天前
已完结
Discovery of Daraxonrasib (RMC-6236), a Potent and Orally Bioavailable RAS(ON) Multi-selective, Noncovalent Tri-complex Inhibitor for the Treatment of Patients with Multiple RAS-Addicted Cancers
1个月前
已完结
Expanding drug targets for 112 chronic diseases using a machine learning-assisted genetic priority score
1个月前
已完结
Temporal phosphorylation of the kinase NEK7 by the kinase Plk1 is essential for mitotic progression
1个月前
已关闭
A PLK1- phospho-regulated code for timely degradation of the mitotic regulator NEK7
1个月前
已关闭
NEK7 phosphorylation amplifies NLRP3 inflammasome activation downstream of potassium efflux and gasdermin D
2个月前
已完结
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