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David
Lv2
180 积分
2022-04-28 加入
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Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of ((S)-2,2-Difluorocyclopropyl)((1R,5S)-3-(2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841)
7小时前
待确认
Akt Inhibitor Advancements: From Capivasertib Approval to Covalent-Allosteric Promises
4天前
已完结
Discovery of LLC0424 as a Potent and Selective in Vivo NSD2 PROTAC Degrader
4天前
已完结
Therapeutic potential of a synthetic dual JAK1/TYK2 inhibitor in inflammatory bowel disease
11天前
已完结
Physicochemical Space for Optimum Oral Bioavailability: Contribution of Human Intestinal Absorption and First-Pass Elimination
22天前
已完结
Design, synthesis and biological evaluation of novel imidazopyridines as potential antidiabetic GSK3β inhibitors
1个月前
已完结
Discovery of Tetrahydropyridopyrimidines as Irreversible Covalent Inhibitors of KRAS-G12C with In Vivo Activity
1个月前
已完结
Design and synthesis of bridged piperidine and piperazine isosteres
1个月前
已完结
Exploring the next generation of antibody–drug conjugates
1个月前
已完结
Identification of novel and potent PROTACs targeting FAK for non-small cell lung cancer: Design, synthesis, and biological study
1个月前
已完结
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