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10 积分 2025-01-08 加入
Drugging non-canonical kinases in cancer therapeutics: Molecular targets, underlying mechanisms and small-molecule inhibitors
3小时前
已完结
Matrix stiffness promotes corneal fibrosis through the YAP/TAZ–β-catenin mechanotransduction pathway: Proteomic and functional validation
4天前
已完结
Selective targeting of endothelial and perivascular angiocrine ROCK2 treats liver fibrosis
4天前
已完结
Identification of Novel Imidazo[1,2- b ]pyridazine Derivatives as Selective ROCK2 Inhibitors for the Treatment of Pulmonary Fibrosis
4天前
已完结
The PKM2 activator and molecular glue TP-1454 modulates tumor-immune responses by destabilizing T-regulatory cells
10天前
已完结
A Review on the Role of Pyruvate Kinase M2 in Cancer: From Metabolic Switch to Transcriptional Regulation
10天前
已完结
Thiazole-Based Tumor Pyruvate Kinase M2 Inhibitors: A Paradigm-Shifting Therapeutic Strategy Targeting Metabolic and Microbial Synergy in Colorectal Cancer
12天前
已完结
Targeting focal adhesion kinase (FAK) for cancer therapy: FAK inhibitors, FAK-based dual-target inhibitors and PROTAC degraders
12天前
已完结
Application of Bioisosteres in the Design and Discovery of FDA-Approved Drugs and Advanced Clinical Candidates
13天前
已完结
Use of Human Dose Prediction Metrics to Enable Discovery of AZD3470, an MTA-Cooperative PRMT5 Inhibitor in Clinical Evaluation
13天前
已完结
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