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26 积分 2024-12-13 加入
Rational Design of Potent and Orally Efficacious PI3Kα/δ Degrader for PIK3CA Mutant Breast Cancer without Hyperglycemic Liability
4天前
已完结
First-in-Class Quinoline-Dione-Derived PROTACs: Potent Degraders of Cdc25 Phosphatases for Antitumor Therapy
4天前
已完结
Discovery of Novel Alkynylbenzene Scaffold-Based PTPN2-Selective Degrader PD-305 with Exceptional Potency and In Vivo Efficacy
5天前
已完结
Targeted Degradation of Prolyl Hydroxylase Domain Enzyme 1 (PHD1) as a Novel Therapeutic Strategy for Acetaminophen-Induced Acute Liver Injury
5天前
已完结
Exploiting E3 ligases for lung cancer therapy: The promise of DCAF-PROTACs
17天前
已完结
Abstract LB037: A systematic mass spectrometry-based chemoproteomic platform (chomiXdegradeTM) for molecular glue degrade discovery and mechanistic dissection
17天前
已关闭
DCAF16-Based Covalent Degradative Handles for the Modular Design of Degraders
1个月前
已完结
DCAF16-Based Covalent Molecular Glues for Targeted Protein Degradation of Histone Deacetylase
1个月前
已关闭
Structure-Guided Optimization of DCAF16 Covalent Ligands
1个月前
已完结
Cyanoacrylamide Warheads for Reversible Covalent DCAF16 Molecular Glues
1个月前
已完结
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