Lv4
738 积分 2022-07-24 加入
AI-driven PROTAC design overcomes oncogenic resilience by eliminating the CLIP1–LTK fusion protein
10小时前
已完结
Two Mechanisms OneMolecule: Developing a ‘Truly’Bifunctional Degrader Targeting Rpn13 and CRBN
14天前
已关闭
Self-Splicing RNA Platform Encodes Twin PROTACs for Dual-E3 Ligase Recruitment and Programmable Protein Degradation
21天前
已完结
Design and Development of DNA Damage Chemical Inducers of Proximity for Targeted Cancer Therapy
1个月前
已完结
Pharmacological targeting of IRF4 as a therapeutic strategy for multiple myeloma
1个月前
已完结
Oncometabolite 5-IP7 inhibits inositol 5-phosphatase to license E-cadherin endocytosis
2个月前
已完结
Structure-guided design of 7-azaindole DNMT1 inhibitors active against hypomethylating agent–resistant acute myeloid leukemia
2个月前
已完结
Targeted degradation of c-Myc through the midnolin–proteasome pathway
3个月前
已完结
MYC in cancer: from undruggable target to clinical trials
3个月前
已完结
Discovery of Daraxonrasib (RMC-6236), a Potent and Orally Bioavailable RAS(ON) Multi-selective, Noncovalent Tri-complex Inhibitor for the Treatment of Patients with Multiple RAS-Addicted Cancers
3个月前
已完结
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