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2599 积分 2021-01-15 加入
Evolving Strategies for Previously Drugged Therapeutic Targets: Medicinal Chemistry Insights from Paradigmatic Cases
2小时前
待确认
Targeting Metallo-β-Lactamases: Discovery of Novel Dihydro-Chromeno Pyrrole (dCPs) Derivatives for Combating Drug-Resistant Infections
7天前
已完结
Targeted Degradation of Bromodomain-Containing Protein 4 Enabled by Reactive Oxygen Species–Activatable NanoPROTACs as an Efficient Strategy to Reverse Liver Fibrosis in Chronic Liver Injury
14天前
已完结
Discovery of APH02174 as a Highly Selective and Orally Bioavailable IRAK4 Degrader for the Treatment of Inflammatory Diseases
16天前
已完结
Piperazinotriazole-based NK3R antagonists: Rational design, synthesis, and identification of an orally active lead compound
22天前
已完结
New PROTAC Designs for Targeted Protein Degradation in 2021–2025: Novel E3 Ligases and Pre-PROTACs
22天前
已完结
Identification of XZ8078 as a Dual-Target Degrader Targeting PARP1 and IKZF3 for Broad Spectrum Anticancer Treatment
22天前
已完结
Design, synthesis, and biological evaluation of novel molecules as potent inhibitors of PLK1
27天前
已完结
NMS-P937, a 4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline derivative as potent and selective Polo-like kinase 1 inhibitor
28天前
已完结
NMS-P937, an Orally Available, Specific Small-Molecule Polo-like Kinase 1 Inhibitor with Antitumor Activity in Solid and Hematologic Malignancies
28天前
已完结
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