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828 积分 2025-02-21 加入
Self-Assembling Amphiphilic PROTACs: A Chemical Strategy for Improved EGFR-Targeted Protein Degradation
6小时前
待确认
Radiokinetics, pharmacokinetics, mass balance and excretion, and metabolism of radiolabeled PROTAC® androgen receptor degrader bavdegalutamide (ARV-110) following intravenous and oral administration in rats
9天前
已完结
Harnessing FBXO31 with Terminal Amide-Functionalized Molecules for Targeted Protein Degradation
18天前
已完结
Targeted degradation of USP7 in solid cancer cells reveals distinct effects of deubiquitinase degraders and inhibitor
1个月前
已关闭
Pharmacokinetics and Metabolism of ARV‐393, a BCL6 PROTAC Degrader, in Dogs by UPLC–MS/MS and UPLC‐Q‐Exactive Orbitrap‐HRMS
1个月前
已完结
PROTAC Delivery Strategies for Overcoming Physicochemical Properties and Physiological Barriers in Targeted Protein Degradation
1个月前
已完结
Design, synthesis, and biological evaluation of quinazolin-4(3H)-one derivatives co-targeting poly(ADP-ribose) polymerase-1 and bromodomain containing protein 4 for breast cancer therapy
1个月前
已完结
Design, synthesis and mechanism studies of novel dual PARP1/BRD4 inhibitors against pancreatic cancer
1个月前
已完结
Photo‐click Proteolysis‐Targeting Chimeras Enable Intracellular Generation of PROTACs for Precise Dual Protein Degradation
1个月前
已完结
Photo‐click Proteolysis‐Targeting Chimeras Enable Intracellular Generation of PROTACs for Precise Dual Protein Degradation
1个月前
已完结
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