Lv7
4740 积分 2021-09-03 加入
Safety considerations for cereblon-recruiting targeted protein degraders
29天前
已完结
Property-Based Optimization of Cereblon-Based Molecular Glue Degraders
1个月前
已完结
Evaluation of Cereblon-Directing Warheads for the Development of Orally Bioavailable PROTACs
1个月前
已完结
Property- and Structure-Guided Discovery of a Tetrahydroindazole Series of Interleukin-2 Inducible T-Cell Kinase Inhibitors
2个月前
已完结
The advantages of describing covalent inhibitor in vitro potencies by IC50 at a fixed time point. IC50 determination of covalent inhibitors provides meaningful data to medicinal chemistry for SAR optimization
2个月前
已完结
Identification of an allosteric site on the E3 ligase adapter cereblon
2个月前
已完结
Identification of 2,4-Diaminopyrimidine Derivatives as Novel Gut-Restricted Selective JAK1 Inhibitors for the Treatment of Inflammatory Bowel Disease
2个月前
已完结
Substituted 2-Pyridinemethanol derivatives as potent and selective phosphodiesterase-4 inhibitors
2个月前
已完结
Substituted 4-(2,2-diphenylethyl)pyridine-N-oxides as phosphodiesterase-4 inhibitors: SAR study directed toward the improvement of pharmacokinetic parameters
2个月前
已完结
Discovery of L-791,943: A potent, selective, non emetic and orally active phosphodiesterase-4 inhibitor
2个月前
已完结
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