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58 积分 2025-08-05 加入
Abstract 5978: SPR2015, a highly potent and selective KRAS G12D (on) inhibitor, exhibits favorable pharmacokinetic behavior and significant anti-tumor efficacy against colorectal cancer as monotherapy in preclinical models
2天前
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Tumor-produced ammonia is metabolized by regulatory T cells to further impede anti-tumor immunity
2个月前
已完结
Persistent T cell activation and cytotoxicity against glioblastoma following single oncolytic virus treatment in a clinical trial
2个月前
已完结
OR7A10 GPCR engineering boosts CAR-NK therapy against solid tumours
2个月前
已完结
Preclinical In Vivo Activity of the Menin Inhibitor Ziftomenib (KO-539) in Pediatric KMT2A-Rearranged Acute Lymphoblastic Leukemia
3个月前
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Combination Strategies with Menin Inhibitors for Acute Leukemia
3个月前
已完结
Advancing targeted protein degradation for cancer therapy
5个月前
已完结
An allele-agnostic mutant-KRAS inhibitor suppresses tumor maintenance signals and reprograms tumor immunity in pancreatic cancer
7个月前
已完结
Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase
9个月前
已完结
Werner helicase as a therapeutic target in mismatch repair deficient colorectal cancer
9个月前
已完结
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