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42 积分 2023-02-09 加入
Roflumilast, a phosphodiesterase-4 (PDE4) inhibitor, induces respiratory frequency plasticity that is resistant to inflammation in neonatal rat in vitro preparations
7天前
已完结
Amylin: emergent therapeutic opportunities in overweight, obesity and diabetes mellitus
7天前
已完结
Roflumilast for asthma: Efficacy findings in mechanism of action studies
10天前
已完结
Crisaborole Topical Ointment, 2%: A Nonsteroidal, Topical, Anti-Inflammatory Phosphodiesterase 4 Inhibitor in Clinical Development for the Treatment of Atopic Dermatitis
11天前
已完结
Glucagon controls obesity-specific energy expenditure via persistent cAMP/PKA signaling
11天前
已完结
The Pharmacology of Two Novel Long-Acting Phosphodiesterase 3/4 Inhibitors, RPL554 [9,10-Dimethoxy-2(2,4,6-trimethylphenylimino)-3-(N-carbamoyl-2-aminoethyl)-3,4,6,7-tetrahydro-2 H-pyrimido[6,1-a]isoquinolin-4-one] and RPL565 [6,7-Dihydro-2-(2,6-diisopropylphenoxy)-9,10-dimethoxy-4 H-pyrimido[6,1-a]isoquinolin-4-one]
11天前
已完结
Discovery of selective PDE4B inhibitors
16天前
已完结
Lack of efficacy of an inhibitor of PDE4 in phase 1 and 2 trials of patients with nonalcoholic steatohepatitis
16天前
已完结
Discovery, Synthesis, and Biological Evaluation of Novel Quinoline-Based PDE4 Inhibitors with Potent Anti-Chronic Obstructive Pulmonary Disease Activity
17天前
已完结
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