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A New Guidance for the Prediction of Hepatic Clearance in the Early Drug Discovery and Development from the in Vitro-to-in Vivo Extrapolation Method and an Approach for Exploring Whether an Albumin-Mediated Hepatic Uptake Phenomenon Could be Present Under in Vivo Conditions
17小时前
待确认
Metabolomics analysis of serum in pediatric nephrotic syndrome based on targeted and non-targeted platforms
15天前
已完结
Untargeted metabolomics of blood plasma samples of patients with hepatocellular carcinoma
17天前
已完结
Metabolomics study by metabolite profiling analysis in kidney and liver of calorie-restricted aging rats using GC-MS/MS
18天前
已完结
High throughput HPLC-ESI-MS method for the quantitation of dexamethasone in blood plasma
21天前
已完结
Serum metabolome alterations in hyperhomocysteinemia based on targeted and non-targeted MS-platforms
27天前
已完结
Sedative-Hypnotic Effects of Yiyin Anshen Granule on Mice Models of Insomnia by Regulating Neurotransmitters, Cytokines, and Gut Microbiota
1个月前
已完结
A New Version of the Tissue Composition-Based Model for Improving the Mechanism-Based Prediction of Volume of Distribution at Steady-State for Neutral Drugs
1个月前
已完结
Determination of Intrinsic Clearance and Fraction Unbound in Human Liver Microsomes and In Vitro-In Vivo Extrapolation of Human Hepatic Clearance for Marketed Central Nervous System Drugs
1个月前
已完结
First-in-Human Predictions of Hepatic Clearance for Drugs With the Well-Stirred Model: Comparative Assessment Between Models of Fraction Unbound Based Either on the Free Drug Hypothesis, Albumin-Facilitated Hepatic Uptake or Dynamic Binding Kinetics
1个月前
已完结
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