细胞激素风暴
免疫学
医学
肺炎
免疫系统
冠状病毒
细胞因子
细胞因子释放综合征
疾病
炎症
2019年冠状病毒病(COVID-19)
传染病(医学专业)
免疫疗法
内科学
嵌合抗原受体
作者
Amirhossein Mardi,Sepideh Meidaninikjeh,Sepideh Nikfarjam,Naime Majidi Zolbanin,Reza Jafari
出处
期刊:Viral Immunology
[Mary Ann Liebert]
日期:2021-12-01
卷期号:34 (10): 679-688
被引量:33
标识
DOI:10.1089/vim.2021.0071
摘要
The newfound coronavirus disease 2019 (COVID-19), initiated by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an international public health concern, threatening the lives of millions of people worldwide. The virus seems to have a propensity to infect older males, especially those with underlying diseases. The cytokine storm following hyperactivated immune responses due to SARS-CoV-2 infection is probably the crucial source of severe pneumonia that leads to acute lung injury, systemic inflammatory response syndrome, or acute respiratory distress syndrome, and finally multiple organ dysfunction syndromes, as well as death in many cases. Several studies revealed that interleukin (IL)-1β levels were elevated during COVID-19 infection. In addition, the IL-1 cytokine family has a pivotal role in the induction of cytokine storm due to uncontrolled immune responses in COVID-19 infection. This article reviews the role of IL-1 in inflammation and utilization of IL-1 inhibitor agents in controlling the inflammatory outcomes initiated by SARS-CoV-2 infection.
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