In vivo labeling and imaging of retinal ganglion cell

Retinal ganglion cells (RGC) damage is an important part of the development of many other retinal and optic nerve diseases. Research on RGC is always a hot topic. RGC labeling methods in vivo mainly include retrograde labeling, intravitreal injection of fluorescence dyes, transgenic mice, electroporation, confocal scanning laser ophthalmoscope (CSLO) combined with fluorescent labeling, optical coherence tomography (OCT), genetically encoded indicators (GECI) imaging, and functional adaptive optical living cell imaging etc. Some labling methods are used in clinical trails. (Int Rev Ophthalmol, 2019, 43: 73-78) Key words: retinal ganglion cell; labeling