心脏纤维化
纤维化
炎症
醛固酮
盐皮质激素受体
内科学
医学
内分泌学
心肌纤维化
血压
封锁
醛固酮增多症
盐皮质激素
受体
作者
Ernesto Martínez‐Martínez,Laurent Calvier,Amaya Fernández‐Celis,Elodie Rousseau,Raquel Jurado-López,Luciana Venturini Rossoni,Frédéric Jaisser,Faı̈ez Zannad,Patrick Rossignol,Victoria Cachofeiro,Natalia López‐Andrés
出处
期刊:Hypertension
[Ovid Technologies (Wolters Kluwer)]
日期:2015-10-01
卷期号:66 (4): 767-775
被引量:132
标识
DOI:10.1161/hypertensionaha.115.05876
摘要
Hypertensive cardiac remodeling is accompanied by molecular inflammation and fibrosis, 2 mechanisms that finally affect cardiac function. At cardiac level, aldosterone promotes inflammation and fibrosis, although the precise mechanisms are still unclear. Galectin-3 (Gal-3), a β-galactoside-binding lectin, is associated with inflammation and fibrosis in the cardiovascular system. We herein investigated whether Gal-3 inhibition could block aldosterone-induced cardiac inflammation and fibrosis and its potential role in cardiac damage associated with hypertension. Aldosterone-salt-treated rats presented hypertension, cardiac inflammation, and fibrosis that were prevented by the pharmacological inhibition of Gal-3 with modified citrus pectin. Cardiac inflammation and fibrosis presented in spontaneously hypertensive rats were prevented by modified citrus pectin treatment, whereas Gal-3 blockade did not modify blood pressure levels. In the absence of blood pressure modifications, Gal-3 knockout mice were resistant to aldosterone-induced cardiac inflammation. In human cardiac fibroblasts, aldosterone increased Gal-3 expression via its mineralocorticoid receptor. Gal-3 and aldosterone enhanced proinflammatory and profibrotic markers, as well as metalloproteinase activities in human cardiac fibroblasts, effects that were not observed in Gal-3-silenced cells treated with aldosterone. In experimental hyperaldosteronism, the increase in Gal-3 expression was associated with cardiac inflammation and fibrosis, alterations that were prevented by Gal-3 blockade independently of blood pressure levels. These data suggest that Gal-3 could be a new molecular mechanism linking cardiac inflammation and fibrosis in situations with high-aldosterone levels, such as hypertension.
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