小胶质细胞
神经退行性变
生物
CX3CR1型
转录组
人脑
神经科学
细胞生物学
免疫系统
先天免疫系统
基因
基因表达
免疫学
炎症
病理
医学
遗传学
趋化因子
趋化因子受体
疾病
作者
Thais Fernanda de Almeida Galatro,Inge R. Holtman,Antônio Marcondes Lerário,Ilia D. Vainchtein,Nieske Brouwer,Paula Rodrigues Sola,Mariana Matera Veras,Túlio Felipe Pereira,Renata Leite,Thomas Möller,Paul D. Wes,Mari C. Sogayar,Jon D. Laman,Wilfred F. A. den Dunnen,Carlos Pasqualucci,Sueli Mieko Oba‐Shinjo,Erik Boddeke,Suely Kazue Nagahashi Marie,Bart J. L. Eggen
摘要
Microglia are essential for CNS homeostasis and innate neuroimmune function, and play important roles in neurodegeneration and brain aging. Here we present gene expression profiles of purified microglia isolated at autopsy from the parietal cortex of 39 human subjects with intact cognition. Overall, genes expressed by human microglia were similar to those in mouse, including established microglial genes CX3CR1, P2RY12 and ITGAM (CD11B). However, a number of immune genes, not identified as part of the mouse microglial signature, were abundantly expressed in human microglia, including TLR, Fcγ and SIGLEC receptors, as well as TAL1 and IFI16, regulators of proliferation and cell cycle. Age-associated changes in human microglia were enriched for genes involved in cell adhesion, axonal guidance, cell surface receptor expression and actin (dis)assembly. Limited overlap was observed in microglial genes regulated during aging between mice and humans, indicating that human and mouse microglia age differently.
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