Synthesis of N‐Difluoromethyl Carbonyl Compounds from N‐Difluoromethylcarbamoyl Fluorides

Abstract Fluorinated small molecules are commonly used in functional small‐molecule chemistry, and N ‐difluoromethyl ( N ‐CF 2 H) compounds are particularly intriguing due to their unique and unexplored physiochemical properties. However, despite limited progress, a general methodological approach to the synthesis of N ‐CF 2 H compounds remains elusive. Here, guided by computation, we present a simple and practical protocol to access N ‐CF 2 H amides and related carbonyl derivatives. The protocol involves a one‐pot conversion of thioformamides through desulfurization‐fluorination and acylation, providing N ‐difluoromethylcarbamoyl fluoride building blocks that can be further diversified to a variety of unexplored N ‐CF 2 H carbonyl compounds with rich functionality. Additionally, preliminary studies on their properties and stability showcased their potential application in pharmaceuticals and agrochemicals.