药剂师
三级护理
中心(范畴论)
多学科方法
万古霉素
多学科团队
医学
家庭医学
护理部
药店
政治学
化学
细菌
遗传学
金黄色葡萄球菌
法学
结晶学
生物
作者
Kittiya Jantarathaneewat,Tuangrat Phodha,Kankanit Singhasenee,Panipak Katawethiwong,Nuntra Suwantarat,Bernard Camins,Thanawat Wongphan,Sasinuch Rutjanawech,Anucha Thatrimontrichai
出处
期刊:Antibiotics
[MDPI AG]
日期:2023-02-11
卷期号:12 (2): 374-374
被引量:1
标识
DOI:10.3390/antibiotics12020374
摘要
Vancomycin Area Under the Curve (AUC) monitoring has been recommended to ensure successful clinical outcomes and minimize the risk of nephrotoxicity, rather than traditional trough concentration. However, vancomycin AUC monitoring by a pharmacist-led multidisciplinary team (PMT) has not been well established in Southeast Asia. This study was conducted at Thammasat University Hospital. Adult patients aged ≥ 18 years who were admitted and received intravenous vancomycin ≥48 h were included. The pre-PMT period (April 2020-September 2020) was defined as a period using traditional trough concentration, while the post-PMT period (October 2020-March 2021) was defined as a period using PMT to monitor vancomycin AUC. The primary outcome was the rate of achievement of the therapeutic target of an AUC/MIC ratio of 400-600. There was a significantly higher rate of achievement of therapeutic target vancomycin AUC during post-PMT period (66.7% vs. 34.3%, p < 0.001). Furthermore, there was a significant improvement in the clinical cure rate (92.4% vs. 69.5%, p < 0.001) and reduction in 30-day ID mortality (2.9% vs. 12.4%, p = 0.017) during the post-PMT period. Our study demonstrates that PMT was effective to help attain a targeted vancomycin AUC, improve the clinical cure rate, and reduce 30-day ID mortality. This intervention should be encouraged to be implemented in Southeast Asia.
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