微泡
外体
血管生成
转移
免疫系统
癌症研究
癌症
功能(生物学)
小RNA
药物输送
细胞
上皮-间质转换
细胞生物学
核酸
间充质干细胞
生物
细胞信号
癌细胞
化学
信号转导
免疫学
生物化学
基因
有机化学
遗传学
作者
Jinyi Liu,Liwen Ren,Sha Li,Lijuan Wan,Xiangjin Zheng,Yihui Yang,Weiqi Fu,Jie Yi,Jinhua Wang,Guanhua Du
标识
DOI:10.1016/j.apsb.2021.01.001
摘要
Exosomes are cell-derived nanovesicles with diameters from 30 to 150 nm, released upon fusion of multivesicular bodies with the cell surface. They can transport nucleic acids, proteins, and lipids for intercellular communication and activate signaling pathways in target cells. In cancers, exosomes may participate in growth and metastasis of tumors by regulating the immune response, blocking the epithelial-mesenchymal transition, and promoting angiogenesis. They are also involved in the development of resistance to chemotherapeutic drugs. Exosomes in liquid biopsies can be used as non-invasive biomarkers for early detection and diagnosis of cancers. Because of their amphipathic structure, exosomes are natural drug delivery vehicles for cancer therapy.
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