Corticosteroids and ICU Course of Community Acquired Pneumonia in Egyptian Settings

Background: Pneumonia is the most common cause of community-acquired infection requiring ICU admission.60% -87% of patients with severe community acquired pneumonia (CAP) admitted to the ICU develops respiratory failure and require mechanical ventilation (MV).Objectives: To assess the efficacy and safety of adjunctive low dose hydrocortisone infusion treatment in Egyptian ICU patients with CAP.Methods: Hospitalized patients, clinically and radiologically diagnosed with CAP, were randomized to receive hydrocortisone 12.5 mg/h IV infusion for 7 days or placebo, along with antibiotics.The end-points of the study were improvement in PaO 2 :FIO 2 (PaO 2 :FIO 2 > 300 or ≥ 100 increase from study entry) and SOFA score by study day 8 and the development of delayed septic shock.Results: 80 patients were recruited, 40 of them received hydrocortisone and the remaining 40 received placebo.By study day 8, hydrocortisone treated patients showed a significant improvement in PaO 2 :FIO 2 and chest radiograph score, and a significant reduction in C-reactive protein (CRP) levels, Sepsis-related Organ Failure Assessment (SOFA) score, and delayed septic shock compared to the control group.Hydrocortisone treatment was associated with a significant reduction in the duration of MV.However, hydrocortisone infusion did not show significant difference in the ICU mortality.Conclusions: adjunctive 7-day course of low dose hydrocortisone IV in patients with CAP hastens recovery of pneumonia and prevents the development of sepsis related complications with a significant reduction in duration of the mechanical ventilation.