| 标题 |
Allergic bronchopulmonary aspergillosis in pediatric patients with cystic fibrosis
囊性纤维化儿童患者发生过敏性支气管肺炎曲菌病
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摘要：Allergic bronchopulmonary aspergillosis (ABPA) is hypersensitive IgE-associated reaction, which occurs as a response of predisposed host to the colonisation of bronchial tree by fungal pathogen Aspergillus fumigatus with production of specific IgE antibodies against certain aspergillus antigens. It occurs almost exclusively in patients with cystic fibrosis or asthma. The disease manifests with increased frequency of pulmonary exacerbations not responding well to conventional therapy, while these exacerbations are characterised by increased mucus and sputum production as well as recurrect attacks of bronchial obstruction. If ABPA is not diagnosed and treated soon enough, it could cause accelerated progression of pulmonary fibrotisation together with the development of cylindrical central bronchiectasis and also lead to irreversible airway damage.………… 年份：2019 |
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