| 标题 |
CONCOMITANT PPI USE NEGATES ORAL BISPHOSPHONATE ANTI-FRACTURE EFFICACY: a POST HOC ANALYSIS FROM A RANDOMIZED CONTROLLED TRIAL OF CLODRONATE
同时使用PPI否定口服双膦酸盐抗骨折疗效：氯膦酸盐随机对照试验的事后分析
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| 其它 | Objectives: Oral bisphosphonates are frequently co‐prescribed with antacid drugs that may interact with bisphosphonate anti‐fracture efficacy [1], We explored the relationship between antacid use and clodronate efficacy on osteoporotic fracture risk within a well‐documented, randomised, placebo‐controlled study. Material and methods: Concurrent medication use at baseline was used to identify those prescribed proton pump inhibitors (PPI), histamine 2 receptor antagonists (H2RA) or other antacids (OAA). Results: Of 5212 women recruited to the trial, 1339 (25.7%) were taking at least one antacid at entry, of whom 451 took H2RA (8.7%), 436 took PPI (8.4%) and 652 took OAA (12.5%, predominantly [89%] sodium alginate‐based products). |
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