| 标题 |
The lysosomal lipid transporter LIMP-2 is part of lysosome–ER STARD3-VAPB-dependent contact sites
溶酶体脂质转运蛋白LIMP-2是溶酶体-ER STARD3-VAPB依赖性接触位点的一部分
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| 其它 | LIMP-2 (also known as SCARB2) is an abundant lysosomal membrane protein. Previous studies have shown that LIMP-2 functions as a virus receptor, a chaperone for lysosomal enzyme targeting and a lipid transporter. The large luminal domain of LIMP-2 contains a hydrophobic tunnel that enables transport of phospholipids, sphingosine and cholesterol from the lysosomal lumen to the membrane. The question about the fate of the lipids after LIMP-2-mediated transport is largely unexplored. |
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