| 标题 |
 Portable miRNA profiling of sepsis-associated exosomes via a novel DNA molecular lock-mediated nanobiosensor 通过一种新型DNA分子锁介导的纳米生物传感器对脓毒症相关外来体的便携式miRNA图谱
相关领域
小RNA
微泡
仿形（计算机编程）
败血症
计算生物学
DNA
外体
化学
生物
纳米技术
基因
材料科学
计算机科学
生物化学
免疫学
操作系统
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| 其它 | Sepsis represents a life-threatening systemic inflammatory condition characterized by organ dysfunction, where the identification of specific biomarkers and development of effective diagnostic modalities are critical for timely clinical intervention to mitigate disease progression. Emerging evidence positions exosomal microRNAs (exomiRs) as promising novel biomarkers with multi-dimensional clinical utility spanning early diagnosis, therapeutic efficacy assessment, and longitudinal prognostic monitoring in sepsis management. However, the direct rapid detection of exomiRs in clinical specimens undergoes severe critical challenges due to the absence of robust detection methodologies with these characteristics of operational simplicity, high sensitivity and analytical robustness. |
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