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[高分] Characterization of Sequence and Structural Features of the Candida krusei Enolase
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烯醇化酶
克鲁斯假丝酵母
生物
热带假丝酵母
生物化学
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In silico biology Pub Date : 2008-01-01 Neha S Gandhi,Kathy Young,John R Warmington,Ricardo L Mancera The incidence of human infections by the fungal pathogen Candida species has been increasing in recent years. Enolase is an essential protein in fungal metabolism. Sequence data is available for human and a number of medically important fungal species. An understanding of the structural and functional features of fungal enolases may provide the structural basis for their use as a target for the development of new anti-fungal drugs. We have obtained the sequence of the enolase of Candida krusei (C. krusei), as it is a significant medically important fungal pathogen. We have then used multiple sequence alignments with various enolase isoforms in order to identify C. krusei specific amino acid residues. The phylogenetic tree of enolases shows that the C. krusei enolase assembles on the tree with the fungal genes. Importantly, C.太长了 |
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2021-07-20 00:28:17 发布，悬赏 50 积分
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